Ion channels take center stage: twin spotlights on two anesthetic targets.
نویسنده
چکیده
6. Stone LS, MacMillan LB, Kitto KF, Limbird LE, Wilcox GL: The a2a adrenergic receptor subtype mediates spinal analgesia evoked by a2 agonists and is necessary for spinal adrenergic-opioid synergy. J Neurosci 1997; 17:7157-65 7. MacMillan LB, Hein L, Smith MS, Piascik MT, Limbird LE: Central hypotensive effects of the a2a-adrenergic receptor subtype. Science 1996; 273:801-3 8. Link RE, Desai K, Hein L, Stevens MS. Chruscinski A, Bernstein D, Barash GS, Kobilka BK: Cardiovascular regulation in mice lacking a2-adrenergic receptor subtypes b and c. Science 1996; 2732303-5 9. Sallinen J, Haapalinna A, Viitamaa T, Kobilka BK, Scheinin M: I>-Amphetamine and L-5-hydroxytryptophan-induced behaviours in mice with genetically-altered expression of the a2C-adrenergic receptor subtype. Neuroscience 1998; 86959 65 122:133944
منابع مشابه
Inhibitory ligand-gated ion channels as substrates for general anesthetic actions.
General anesthetics have been in clinical use for more than 160 years. Nevertheless, their mechanism of action is still only poorly understood. In this review, we describe studies suggesting that inhibitory ligand-gated ion channels are potential targets for general anesthetics in vitro and describe how the involvement of y-aminobutyric acid (GABA)(A) receptor subtypes in anesthetic actions cou...
متن کاملAnesthetics and ion channels: molecular models and sites of action.
The mechanisms of general anesthesia in the central nervous system are finally yielding to molecular examination. As a result of research during the past several decades, a group of ligand-gated ion channels have emerged as plausible targets for general anesthetics. Molecular biology techniques have greatly accelerated attempts to classify ligand-gated ion channel sensitivity to general anesthe...
متن کاملStructure of the pentameric ligand-gated ion channel GLIC bound with anesthetic ketamine.
Pentameric ligand-gated ion channels (pLGICs) are targets of general anesthetics, but a structural understanding of anesthetic action on pLGICs remains elusive. GLIC, a prokaryotic pLGIC, can be inhibited by anesthetics, including ketamine. The ketamine concentration leading to half-maximal inhibition of GLIC (58 μM) is comparable to that on neuronal nicotinic acetylcholine receptors. A 2.99 Å ...
متن کاملTwin Plate Weir: A Flow Measuring Device (TECHNICAL NOTE)
For efficient use of water, accurate measurement of flow in (field/laboratory) channels is required for many water resource projects. The present work is aimed to study the flow characteristics of a twin plate weir (two sharp-crested plates are placed one behind the other at some distance) under free and submerged flow conditions. Experiments are performed with four spacing of the twin plate we...
متن کاملA membrane-embedded pathway delivers general anesthetics to two interacting binding sites in the Gloeobacter violaceus ion channel
General anesthetics exert their effects on the central nervous system by acting on ion channels, most notably pentameric ligand-gated ion channels. Although numerous studies have focused on pentameric ligand-gated ion channels, the details of anesthetic binding and channel modulation are still debated. A better understanding of the anesthetic mechanism of action is necessary for the development...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Anesthesiology
دوره 92 4 شماره
صفحات -
تاریخ انتشار 2000